+ampliar imagen

Masivo estudio randomizado desaconseja el uso de antioxidantes

La suplementación con 1 gr de Vitamina C y 400 UI de Vitamina E administradas desde la primera mitad del embarazo (9-16 semanas) no redujo las complicaciones maternas o neonatales asociadas a la hipertensión del embarazo. El estudio, que incluyó 10.154 pacientes, se publicó esta semana en el NEJM y fue conducido por el network de medicina materno-fetal del National Institutes of Health de Estados Unidos.

Vitamins C and E to Prevent Complications of Pregnancy-Associated Hypertension
James M. Roberts, M.D. et al

Background Oxidative stress has been proposed as a mechanism linking the poor placental perfusion characteristic of preeclampsia with the clinical manifestations of the disorder. We assessed the effects of antioxidant supplementation with vitamins C and E, initiated early in pregnancy, on the risk of serious adverse maternal, fetal, and neonatal outcomes related to pregnancy-associated hypertension.

Methods We conducted a multicenter, randomized, double-blind trial involving nulliparous women who were at low risk for preeclampsia. Women were randomly assigned to begin daily supplementation with 1000 mg of vitamin C and 400 IU of vitamin E or matching placebo between the 9th and 16th weeks of pregnancy. The primary outcome was severe pregnancy-associated hypertension alone or severe or mild hypertension with elevated liver-enzyme levels, thrombocytopenia, elevated serum creatinine levels, eclamptic seizure, medically indicated preterm birth, fetal-growth restriction, or perinatal death.

Results A total of 10,154 women underwent randomization. The two groups were similar with respect to baseline characteristics and adherence to the study drug. Outcome data were available for 9969 women. There was no significant difference between the vitamin and placebo groups in the rates of the primary outcome (6.1% and 5.7%, respectively; relative risk in the vitamin group, 1.07; 95% confidence interval [CI], 0.91 to 1.25) or in the rates of preeclampsia (7.2% and 6.7%, respectively; relative risk, 1.07; 95% CI, 0.93 to 1.24). Rates of adverse perinatal outcomes did not differ significantly between the groups.

Conclusions Vitamin C and E supplementation initiated in the 9th to 16th week of pregnancy in an unselected cohort of low-risk, nulliparous women did not reduce the rate of adverse maternal or perinatal outcomes related to pregnancy-associated hypertension (ClinicalTrials.gov number, NCT00135707).

ver más información de esta noticia acá › ◦ volver ›

• Imprímela
• Envíala a un Amigo
• Ver más

• Meta-análisis muestra que aspirina iniciada tempranamente reduce RCIU y preeclampsia14.08.2010
• ACOG publica nuevas guías para la prueba de parto post-cesárea14.08.2010
• Acido valproico se asocia significativamente con al menos 6 malformaciones congénitas20.07.2010
• Nuevas guias ACOG para trombofilias y embarazo20.07.2010
• Estudio sugiere mejor pronóstico cuando la histerorrafia se sutura en 2 capas28.06.2010
• Distocia de hombros es sólo una de las causas de parálisis braquial03.06.2010